Abstract

Abstract

The Raman spectra (1800-200 cm(-1)) of isolated dried collagen types I and III were recorded at different times after shockwave (SW) application in aqueous media. SWs were applied in a single session. One week after the SW application the vibrational data analysis indicates changes in the conformation of the collagens; orientational changes are also inferred. During the next three weeks collagens tended to recover the conformation and orientation existing before SW application.

Copyright © 2011 Elsevier B.V. All rights reserved.

Spectrochim Acta A Mol Biomol Spectrosc. 2012 Feb;86:360-5. doi: 10.1016/j.saa.2011.10.049. Epub  2011 Oct 25

PMID: 22079890 [PubMed - in process]

Comment

Comment

Shock waves are not only used for stone fragmentation but for many different diseases such as chronic pelvic pain syndrome, chronic pain in general, pseudarthrosis, wound healing, cardiac diseases etc. The working mechanism for these diseases is poorly understood. The authors investigate the effect of shock waves on isolated dried collagen types I and III by Raman spectroscopy in vitro. Raman spectroscopy is well suited to characterize structural features of collagen as well as changes which might be due to shock wave application. Changes of Raman spectra could be shown to develop within one week after shock wave application returning to original values after three weeks. This observation may help to understand shock wave effects on collagen tissue and may lead the way towards future in vivo investigations.

Othmar Wess