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Connors BA et al, 2018: Preliminary Report on Stone Breakage and Lesion Size Produced by a New Extracorporeal Electrohydraulic (Sparker Array) Discharge Device.

Connors BA, Schaefer RB, Gallagher JJ, Johnson CD, Li G, Handa RK, Evan AP.
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN.
Phoenix Science and Technology, Goffstown, NH.
School of Physics, Northeast Normal University, Changchun, China.

Abstract

OBJECTIVE: To determine if an innovative extracorporeal electrohydraulic shock wave (SW) device (sparker array [SPA]) can effectively fracture artificial stones in vitro and in vivo, and if SPA treatment produces a renal lesion in our pig model of lithotripsy injury. Results of these experiments will be used to help evaluate the suitability of this device as a clinical lithotripter.
MATERIALS AND METHODS: Ultracal-30 artificial stones were placed in a holder at the focus of the SPA and treated with 600 SWs (21.6 kV, 60 shocks/min). Stone fragments were collected, dried, and weighed to determine stone breakage. In vivo stone breakage entailed implanting stones into pigs. These stones were treated with 600 or 1200 SWs and the fragments were collected for analysis. Lesion analysis consisted of treating the left kidney of pigs with 1200 or 2400 SWs and quantitating the hemorrhagic lesion.
RESULTS: In vitro, 71% ± 2% of each artificial stone was fractured to <2 mm in size. In vivo stone breakage averaged 63%. Renal injury analysis revealed that only 1 of 7 kidneys showed evidence of hemorrhagic injury in the treated area.
CONCLUSION: The SPA consistently comminuted artificial stones demonstrating its ability to fracture stones like other lithotripters. Also, the SPA caused little to no renal injury at the settings used in this study. These findings suggest further research is warranted to determine the potential of this device as a clinical lithotripter.

Urology. 2018 Jun;116:213-217. doi: 10.1016/j.urology.2018.03.020. Epub 2018 Mar 27.

 

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Comments 1

Hans-Göran Tiselius on Wednesday, 03 October 2018 08:41

This is an interesting report on in-vitro (artificial stones) and in-vivo (pigs) results with a new sparker array (SPA) extracorporeal electrohydraulic discharge device. With this new technique there was a good disintegration of stones and in the animal experiment essentially without any tissue damage. The latter observation is the main difference compared with other lithotripters. The further experience with the aim of developing a new clinical lithotripter is anticipated with interest.

This is an interesting report on in-vitro (artificial stones) and in-vivo (pigs) results with a new sparker array (SPA) extracorporeal electrohydraulic discharge device. With this new technique there was a good disintegration of stones and in the animal experiment essentially without any tissue damage. The latter observation is the main difference compared with other lithotripters. The further experience with the aim of developing a new clinical lithotripter is anticipated with interest.
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