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Deng T et al, 2015: New-onset diabetes mellitus after shock wave lithotripsy for urinary stone: a systematic review and meta-analysis.

Deng T, Liao B, Tian Y, Luo D, Liu J, Jin T, Wang K.
Department of Urology Surgery, West China School of Medicine/West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan Province, People's Republic of China.

Abstract

The purpose of the study was to evaluate the association between shock wave lithotripsy (SWL) for urinary stone and new-onset diabetes mellitus (DM). A comprehensive data collection was performed in the Pubmed database, Embase database, Chinese Biomedical database, Chinese National Knowledge Infrastructure database and VIP database. Difference in incidence of new-onset DM after SWL between cases and controls was evaluated by odds ratio (OR) with its 95 % confidence interval (CI). And summary adjusted risk ratios (RRs) and 95 % CIs were calculated to assess the strength of association between SWL and new-onset DM, and then subgroup analyses were conducted. Five studies were included in this meta-analysis. The incidence of new-onset DM after SWL is not higher than that in the population who do not receive SWL [OR = 1.59, 95 % CI (0.92, 2.74), P = 0.10]. And statistical association between SWL and new-onset DM could not be found
significantly [RR = 1.33, 95 % CI (0.83, 2.13), P = 0.24], either. However, body mass index (BMI) [RR = 1.09, 95 % CI (1.04, 1.14), P < 0.001] and family history of DM (FHx DM) [RR = 0.35, 95 % CI (0.15, 0.80), P = 0.013] were found significantly associated with the development of DM in subgroup analyses. Our data suggests that there is no association between SWL for urinary stone and new-onset DM. 

Urolithiasis. 2015 Mar 10. [Epub ahead of print]

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Comments 1

Hans-Göran Tiselius on Monday, 25 May 2015 09:44

The possible association between SWL and development of diabetes mellitus (DM) is apparently subject to continuous interest in the literature. This article is a meta-analysis of data found in five articles dealing with this issue. Also this review failed to demonstrate any statistically significant relationship between SWL and subsequent onset of DM. The authors noted that family history of DM and high BMI were the major risk factors for development of DM. This observation supports previous conclusions that the relationship rather is between stone disease itself and DM than between SWL and DM. The higher risk of DM in stone formers has added to the difficulties of appropriate interpretation of the reason for appearance of DM in SWL-treated patients.

The possible association between SWL and development of diabetes mellitus (DM) is apparently subject to continuous interest in the literature. This article is a meta-analysis of data found in five articles dealing with this issue. Also this review failed to demonstrate any statistically significant relationship between SWL and subsequent onset of DM. The authors noted that family history of DM and high BMI were the major risk factors for development of DM. This observation supports previous conclusions that the relationship rather is between stone disease itself and DM than between SWL and DM. The higher risk of DM in stone formers has added to the difficulties of appropriate interpretation of the reason for appearance of DM in SWL-treated patients.
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