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Erturham S et al, 2014: Limitation of hif-1α with pentoxifillyne on renal tubular ischemia result of hiperoxaluria and ESWL

Erturham S, Bayrak O, Seckiner I, Celik M, Karakok M
Department of Urology. Department of Anatomopathology. Gaziantep University. Gaziantep. Turkey


Abstract

OBJECTIVES: To evaluate hypoxia-inducible factor 1 subunit α (HIF-1α) expression during the performance of extracorporeal shock wave lithotripsy (ESWL) and to investigate the effects of pentoxyphylline on HIF-1α expression.

METHODS: One hundred New Zealand Albino rabbit were used in the study divided in 5 groups. There were 20 rabbits in each group. The groups were divided in two parts: early (7 days) and late period (14 days) according to follow up duration. Immunohistochemical analyses were performed using nuclear staining to show HIF-1α expression in rabbit renal tissue sample.

RESULTS: HIF-1α expression was higher in rabbits undergoing ESWL (group 4). In the hyperoxaluria group taking pentoxyphylline before ESWL (group 5), HIF-1α expression was lower in both early and late period subgroups (p < 0.05)

CONCLUSION: In this study we evaluated HIF-1α expression and showed that ESWL may cause renal cell injury. Our results suggest that pentoxyphylline, as a circulatory regulator agent, may prevent renal cell injury induced by ESWL.

Article in Spanish

Arch Esp Urol. 2014 Mar;67(2):191-197.
PMID:24691042[PubMed - as supplied by publisher]

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Hans-Göran Tiselius on Wednesday, 22 January 2014 14:07

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Publication's not available in English.
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