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Yilmaz E et al, 2013: Ways in which SWL affects oxidant/antioxidant balance

Yilmaz E, Haciislamoglu A, Kisa U, Dogan O, Yuvanc E, Batislam E
Department of Urology, Faculty of Medicine, University of Kirikkale, Tip Fakultesi, Uroloji AD, Saglik Sokak, 71100, Kirikkale, Turkey


Abstract

Many damages can occur in the kidneys following extracorporeal shock wave lithotripsy (SWL) and some of these damages are thought to emerge as a result of oxidative stress. The objective of this study is to evaluate the impact of SWL application on kidneys in stone patients on oxidative stress parameters in 24-h urine. The study included 20 patients scheduled for SWL. total antioxidant capacity (TAC) and total oxidant status (TOS) measurements were made on 24-h urines of the patients before and after SWL. The oxidative stress index (OSI) was calculated based on these values. Following SWL, while TOS increased in 24-h urine (p = 0.006), TAC remained unchanged (p = 0.312). OSI increased following the procedure (p = 0.004). SWL application disrupts the oxidant/antioxidant balance in favor of oxidants, which leads to oxidative stress. TOS, TAC and OSI may be useful in the determination of the existence of oxidative stress following SWL.

Urolithiasis. 2013 Apr;41(2):137-41. doi: 10.1007/s00240-012-0537-4. Epub 2012 Dec 28
PMID:23503875 [PubMed - in process]

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Comments 1

Hans-Göran Tiselius on Monday, 12 November 2012 06:29

In this interesting study the effects of SWL (3000 sw; 16-22 kV) on the total antioxidant capacity (TAC), total antioxidant status (TOS) and oxidative stress index (OSI) was measured in 24h urine. TOS and OSI were significantly increased, but TOS was not. The effects are ascribed the re-perfusion that follows^reduced renal perfusion after SWL. The report gives no information on the relationship between the production of free radicals and the total shock wave energy administered.

The clinical consequences of the disturbed oxidant/antioxidant balance is unknown, but from a clinical point of view it might be of value to protect the renal tissue by administration of a suitable antioxidant, as also has been suggested in several previous publications. Such a step might be particularly useful for those patients in who repeated SWL sessions and/or high energy levels can be expected.

Hans-Göran Tiselius

In this interesting study the effects of SWL (3000 sw; 16-22 kV) on the total antioxidant capacity (TAC), total antioxidant status (TOS) and oxidative stress index (OSI) was measured in 24h urine. TOS and OSI were significantly increased, but TOS was not. The effects are ascribed the re-perfusion that follows^reduced renal perfusion after SWL. The report gives no information on the relationship between the production of free radicals and the total shock wave energy administered. The clinical consequences of the disturbed oxidant/antioxidant balance is unknown, but from a clinical point of view it might be of value to protect the renal tissue by administration of a suitable antioxidant, as also has been suggested in several previous publications. Such a step might be particularly useful for those patients in who repeated SWL sessions and/or high energy levels can be expected. Hans-Göran Tiselius
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