Meshari A Alzahrani et al., 2024: Comparative efficacy of different surgical techniques for pediatric urolithiasis-a systematic review and meta-analysis
Meshari A Alzahrani 1, Waleed Khalid Z Alghuyaythat 2, Bandar Mohammed B Alsaadoon 2, Abdullah Othman A Aldahash 2, Abdulmohsen Khalid M Alghamdi 3, Faisal Majid S Alshammary 3, Muteb Saeed M Alhodairy 2, Abdulaziz Mfwad A Alanazi 2, Bader Qasi Alotaibi 2, Mohammad Abdullah H Silsilah 2, Abdullah Naser A Alotibi 2, Faisal Khalid I Alhusini 2, Talal Mohammed A Alanazi 2
1Department of Urology, College of Medicine, Majmaah University, Al-Majmaah, Saudi Arabia.
2College of Medicine, Majmaah University, Majmaah, Saudi Arabia.
3College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Abstract
Background: Prior research has assessed a range of surgical treatments for pediatric urolithiasis, emphasizing the necessity of tailor-made therapeutic approaches. These studies also show the adaptability of percutaneous nephrolithotomy (PCNL), retrograde intrarenal surgery (RIRS), and shock wave lithotripsy (SWL) in managing diverse stone dimensions. The goal of this research was to examine the effectiveness of these varying surgical methods in treating pediatric urolithiasis.
Methods: Seven digital databases were explored to gather pertinent studies, following the guidelines established by the PRISMA protocol. The retrieved studies were subsequently scrutinized to draw comparisons between the stone-free rate (SFR) and the rate of complications associated with PCNL, RIRS, and SWL.
Results: The SFR evaluation revealed no notable disparity between PCNL and RIRS [odds ratio (OR) 1.43, 95% confidence interval (CI): 0.67-3.05, P=0.36]. However, it was observed that both PCNL and RIRS outperformed SWL in terms of effectiveness (OR 2.51, 95% CI: 1.19-5.29, P=0.02 and OR 2.42, 95% CI: 1.41-4.14, P=0.001 respectively). Regarding the complication rates, no significant differences were observed among the three surgical methods (OR 0.67, 95% CI: 0.49-1.59, P=0.05), albeit with various forms of complications being reported. Certain studies associated PCNL with an elevated rate of complications, specifically urinary tract infections (UTIs) and severe hematuria.
Conclusions: Though PCNL and RIRS demonstrated higher effectiveness than SWL in achieving SFR, there was no significant disparity in the rates of complications across all three procedures. The study underscores the significance of personalized treatment plans, taking into account aspects such as the dimension and location of the stone, along with patient-specific characteristics.
Transl Androl Urol. 2024 Jul 31;13(7):1127-1144. doi: 10.21037/tau-23-676. Epub 2024 Jul 16.
PMID: 39100831 PMCID: PMC11291404 FREE PMC ARTICLE
Comments 1
A typical, extensive and carefully performed review of 13 authors on finally 13 papers published from 2013 to 2023 not essentially contributing to a new view or intellectual or practical progress. However, this a frequent result of metanalyses. Those readers familiar with the procedures and the literature will have slightly differing views and will not find new aspects which would change their procedures. The casual reader will find it a little confusing. Both readers will find it difficult to adapt to the “significance of personalized treatment plans” if there is no difference shown between the three techniques.
Peter Alken