Alzheimer’s disease: Transcranial Pulse Stimulation (TPS) with the NEUROLITH system significantly improves brain performance of patients

Transcranial Pulse Stimulation (TPS)

In 2018, Transcranial Pulse Stimulation (TPS®) with the NEUROLITH® system was the first, and hitherto only, procedure of its kind to obtain market authorization for the »treatment of the central nervous system of patients with Alzheimer’s disease«. TPS® was developed by STORZ MEDICAL in collaboration with a team of researchers from the Medical University of Vienna (Department of Neurology), led by Professor Roland Beisteiner, and Dr. Henning Lohse-Busch, Rheintalklinik, Bad Krozingen. In December 2019, the prestigious journal »Advanced Science« published a study, in which Beisteiner et al. evaluate the method and present first treatment results. The presented data shows that it is possible to improve brain performance with TPS® and that there is a long-term effect.

Significant CERAD score improvements and long-term effect
The authors describe TPS® as a new therapy approach. With TPS® it is possible to reach all areas of the brain with TPS® and activate neurons, which can help to regenerate brain functions. As a result, the memory network is boosted, and memory performance improves.

The presented data documents the positive effects of TPS®: In the multicentre pilot study with 35 patients, the CERAD score improved significantly after treatment and remained stable over three months, which indicates a long-term effect. The patients tolerated the treatment well and there were no relevant side effects.

TPS® has great potential
The authors conclude that TPS® represents a promising new therapy option that allows targeted stimulation of cerebral regions. According to a press release of the Medical University of Vienna from 7 January 2020, clinical neuroscientists expect a breakthrough in the treatment of brain diseases if the results of the pilot study are confirmed. Further scientific studies are required to evaluate the stimulation effects.

1) Beisteiner, R. et al.: Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s Disease – A New Navigated Focal Brain Therapy, Adv. Sci. [online ahead of print], DOI: 10.1002/advs.201902583, 2019
Link to full paper:
2) Press release of the Medical University of Vienna from 7 January 2020:

Further information on the new NEUROLITH® system is available on our website.



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Friday, 24 March 2023