TPS around the world: Recent study highlights from Brazil

TPS around the world: Recent study highlights from Brazil

Transcranial Pulse Stimulation (TPS) as a non-invasive brain stimulation method is now accessible in over 43 countries worldwide. The availability of TPS in a growing number of countries reflects its increasing relevance as an add-on treatment option for patients with Alzheimer’s disease. The most recent milestones include the installation of the first NEUROLITH® system in Slovakia and registrations in Thailand and Venezuela. 

The latest scientific data from Brazil on the treatment of Alzheimer’s patients emphasises the potential applications and safety of the method. 

Study from Brazil on TPS 
A recent study from Brazil, titled »Non-invasive sound wave brain stimulation with Transcranial Pulse Stimulation (TPS) improves neuropsychiatric symptoms in Alzheimer’s disease«, conducted by a distinguished team of researchers including Dr Gilson Tanaka Shinzato, Dr Tatiane Assone, and others, is exploring the effects of TPS in patients with Alzheimer’s disease. This research was carried out at the Institute of Physical Medicine and Rehabilitation of Sao Paulo, Brazil, in cooperation with Prof. Felipe Fregni of the Neuromodulation Center of Harvard Medical School, Boston, MA, USA. The prospective, one-arm open-label trial involved ten patients with mild to moderate Alzheimer’s dementia. 6000 pulses of TPS across 10 sessions over five weeks were applied. 

Key Findings 
The study observed a reduction in neuropsychiatric symptoms, which was reflected in a decrease in Neuropsychiatric Inventory (NPI) scores by 23.9 points after 30 days and 18.9 points after 90 days post-treatment. 

Although not statistically significant, a trend towards cognitive improvement was noted, with the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) scores showing a decrease of 3.6 points after 90 days. 

According to the researchers, the findings suggest the potential for an improvement of neuropsychiatric symptoms as well as cognitive enhancement through TPS, warranting further investigation. 

This »preliminary« publication from Brazil – not in the sense of early-stage data but in the context of being the first of its kind in Brazil – lays the groundwork for a larger study that will enrol a total of 50 patients and incorporate a control group. 

Click here to read the full study