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Guan Y et al, 2016: Histotripsy Produced by Hundred-Microsecond-Long Focused Ultrasonic Pulses: A Preliminary Study.

Guan Y, Lu M, Li Y, Liu F, Gao Y, Dong T, Wan M.
Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Abstract

A new strategy is proposed in this study to rapidly generate mechanical homogenized lesions using hundred-microsecond-long pulses. The pulsing scheme was divided into two stages: generating sufficient bubble seed nuclei via acceleration by boiling bubbles and efficiently forming a mechanically homogenized and regularly shaped lesion with a homogenate inside via inertial cavitation. The duty cycle was set at 4.9%/3.9% in stage 1 and 1%/0.88% in stage 2 by changing the pulse duration (PD) and off-time independently. The pulse sequence was 500-μs/400-μs PD with a 100-Hz pulse repetition frequency (PRF) in stage 1, followed by 500-μs/400-μs PD with a 100-Hz PRF and 200-μs PD with a 200-Hz PRF in stage 2. Experiments were conducted on polyacrylamide phantoms with bovine serum albumin and on ex vivo porcine kidney tissues using a single-element 1.06-MHz transducer at an 8-MPa peak negative pressure with shock waves. The lesion evolution and dynamic elastic modulus variation in the phantoms and the histology in the tissue samples were investigated. The results indicate that the two-stage treatment using hundred-microsecond-long pulses can efficiently produce mechanically homogenized lesions with smooth borders, long tear shapes and the total homogenate inside. The time to generate a single mechanically homogenized lesion is shortened from >50 s to 17.1 s.

Ultrasound Med Biol. 2016 Sep;42(9):2232-44. doi: 10.1016/j.ultrasmedbio.2016.01.022. Epub 2016 Jun 16. 

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Comentarios 1

Hans-Göran Tiselius en Miércoles, 08 Marzo 2017 07:34

Histotripsy has recently been described as a method by means of which non-invasive stone disintegration might be improved.

The technique presented and studied in this article (not easy to follow in detail for a urologist) deals with generation of shockwaves induced by 100 sec-long focused ultrasound pulses. The authors have used experimentally a two-stage procedure to generate shockwaves with negative peak pressure of 8 MPa and positive pressures of 35 MPa. Without going into any further details of this system it is obvious that the method is best suited for tissue destruction and tumour treatment.

Whether any modification of this technique in the future might be applicable to stone disintegration is unknown!

Histotripsy has recently been described as a method by means of which non-invasive stone disintegration might be improved. The technique presented and studied in this article (not easy to follow in detail for a urologist) deals with generation of shockwaves induced by 100 sec-long focused ultrasound pulses. The authors have used experimentally a two-stage procedure to generate shockwaves with negative peak pressure of 8 MPa and positive pressures of 35 MPa. Without going into any further details of this system it is obvious that the method is best suited for tissue destruction and tumour treatment. Whether any modification of this technique in the future might be applicable to stone disintegration is unknown!
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