Eker HE et al, 2012: IV paracetamol effect on propofol-ketamine consumption in paediatric patients undergoing ESWL

Eker HE, Cok OY, Ergenoğlu P, Ariboğan A, Arslan G
Department of Anaesthesiology, Baskent University, Dadaloğlu Mah, 39 sok, No: 36, 01250, Yüreğir/Adana, Turkey


PURPOSE: Electroshock wave lithotripsy (ESWL) is a painful procedure performed with sedoanalgesia in paediatric patients. The propofol-ketamine combination may be the preferable anaesthesia for this procedure, and propofol-ketamine consumption may be decreased with the administration of intravenous (IV) paracetamol. In this study we investigated the effect of IV paracetamol administration on propofol-ketamine consumption, recovery time and frequency of adverse events in paediatric patients undergoing ESWL.

METHODS: Sixty children, ranging in age from 1 to 10 years and with American Society of Anesthesiologists Physical Status 1-2, were included in this prospective, randomized, double-blinded study. Thirty minutes prior to the procedure children randomly assigned to Group I received IV 15 mg/kg paracetamol, and those randomly assigned to Group II received 1.5 mL/kg IV saline infusion 30 min. The propofol-ketamine combination was prepared by mixing 25 mg propofol and 25 mg ketamine in a total 10 mL solution in the same syringe. After the administration of 0.1 mg/kg midazolam and 10 μg/kg atropine to both groups and during the procedure, the propofol-ketamine combination was administered at 0.5 mg/kg doses to achieve a Wisconsin sedation score of 1 or 2. Oxygen saturation and heart rate were recorded at 5-min intervals. Propofol-ketamine consumption, recovery times and adverse events were also recorded.

RESULTS: Demographic data were similar between groups. Propofol-ketamine consumption (Group I, 25.2 ± 17.7 mg; Group II, 35.4 ± 20.1 mg; p = 0.04) and recovery times (Group I, 19.4 ± 7.9 min; Group II, 29.6 ± 11.4 min; p < 0.0001) were significantly different between groups. Saturation, heart rate and adverse events were similar in both groups.

CONCLUSION: Our data suggest that the administration of IV paracetamol decreases propofol-ketamine consumption for adequate sedation during ESWL procedures in paediatric patients and shortens recovery time.

J Anesth. 2012 Jun;26(3):351-6. doi: 10.1007/s00540-012-1335-4. Epub 2012 Feb 17
PMID: 22349746 [PubMed - in process]


Comments 1

Peter Alken on Monday, April 09 2012 06:35

Good abstract, good message, good paper.

Peter Alken

Good abstract, good message, good paper. Peter Alken
Friday, September 25 2020

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