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Jeong HC. et al., 2019: Synergistic effects of extracorporeal shockwave therapy and modified Ojayeonjonghwan on erectile dysfunction in an animal model of diabetes

Jeong HC, Bae WJ, Zhu GQ, Jeon SH, Choi SW, Kim SJ, Cho HJ, Hong SH, Lee JY, Hwang SY, Kim SW.
Department of Urology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Catholic Integrative Medicine Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Korea.
KEMIMEDI, Seoul, Korea.

Abstract

Purpose: We investigated the synergy effect of extracorporeal shock wave therapy (ESWT) with modified Ojayeonjonghwan (Korean herbal formula, KH-204) in an animal model of diabetes mellitus (DM)-induced erectile dysfunction (ED).Materials and Methods: Eight-week-old male Sprague-Dawley rats were used in this study. DM was induced by an intraperitoneal injection of streptozotocin. DM rats were divided into 5 groups (n=10 per group): group 1, control; group 2, DM; group 3, DM+ESWT; group 4, DM+KH-204; and group 5, DM+ESWT+KH-204. In ESWT groups, rats were treated with ESWT at the penis 3 times a week for 2 weeks under anesthesia. The KH-204 groups were treated with a daily oral dose of KH-204 for 12 weeks. After all treatments, intracavernosal pressure (ICP) was measured, and the cavernous tissues were evaluated by Masson's trichrome, immunohistochemistry and western blot analysis.Results: ICP was evaluated as a measurement of erectile function. The DM+ESWT, DM+KH-204, and DM+ESWT+KH-204 groups showed significantly restored erectile function compared with the DM group (p<0.05). Among these groups, the DM+ESWT+KH-204 group showed the highest ICP. Moreover, ESWT and KH-204 treatment restored smooth muscle contents and many parameters related to potency (vascular endothelial growth factor, neuronal nitric oxide synthase (NOS), endothelial [NOS] and platelet endothelial cell adhesion molecule-1) compared with the DM group (p<0.05).Conclusions: We confirmed the potential efficacy of ESWT and KH-204 in the treatment of ED patients using an animal model. The combination treatment of KH-204 and ESWT is expected to have good potential clinical results in the future treatment of refractory ED.
Investig Clin Urol. 2019 Jul;60(4):285-294. doi: 10.4111/icu.2019.60.4.285. Epub 2019 Jun 5. Free PMC Article

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Comments 1

Peter Alken on Friday, January 17 2020 08:15

The herbal formula - KH-204 - used in the experiments is a watery extract of 5 different plants which is also commercially available in Korea in a similar version. It seems to be popular for use in andrological problems. One author is employee of the company. A quick glance at the traditional herbal medicine for andrological problems in Korea is offered by Shin et al. (1). In the present rat model with an artificially induced diabetes mellitus (DM) the recordings of the mean intracorporeal penile pressure/mean arterial pressure (ICP/MAP) for the control, DM, DM+ESWT, DM+KH-204, and DM+ESWT+KH-204 groups were 0.88±0.13, 0.25±0.04, 0.47±0.16, 0.40±0.15, and 0.64±0.15. In a 2008 publication from the same institution using a spontaneous hypertensive rat model the values of the untreated hypertensive animals were 14.9±1.4%, and of those treated with the compound only was 62.8±3.9%. The latter value is similar to the one reached in the present experiments with a combination of compound and ESWT. This seems to show that the experimental conditions have a strong influence on the observed effect.
1 Shin Y S et al. Current Status and Clinical Studies of Oriental Herbs in Sexual Medicine in Korea. World J Mens Health 2015 August 33(2): 62-72 http://doi.org/10.5534/wjmh.2015.33.2.62 Free PMC Article

The herbal formula - KH-204 - used in the experiments is a watery extract of 5 different plants which is also commercially available in Korea in a similar version. It seems to be popular for use in andrological problems. One author is employee of the company. A quick glance at the traditional herbal medicine for andrological problems in Korea is offered by Shin et al. (1). In the present rat model with an artificially induced diabetes mellitus (DM) the recordings of the mean intracorporeal penile pressure/mean arterial pressure (ICP/MAP) for the control, DM, DM+ESWT, DM+KH-204, and DM+ESWT+KH-204 groups were 0.88±0.13, 0.25±0.04, 0.47±0.16, 0.40±0.15, and 0.64±0.15. In a 2008 publication from the same institution using a spontaneous hypertensive rat model the values of the untreated hypertensive animals were 14.9±1.4%, and of those treated with the compound only was 62.8±3.9%. The latter value is similar to the one reached in the present experiments with a combination of compound and ESWT. This seems to show that the experimental conditions have a strong influence on the observed effect. 1 Shin Y S et al. Current Status and Clinical Studies of Oriental Herbs in Sexual Medicine in Korea. World J Mens Health 2015 August 33(2): 62-72 doi.org/10.5534/wjmh.2015.33.2.62 [b]Free PMC Article[/b]
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