SWL literature
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Ozmerdiven G et al, 2017: Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats.

Ozmerdiven G, Vuruskan BA, Kaygisiz O, Vuruskan H.

Abstract

BACKGROUND: We aimed to compare the protective effects of tadalafil and diltiazem on renal histology after ischemia and reperfusion injury in a rat model of shock wave lithotripsy.
METHODS: A total of 40 adult, male Sprague-Dawley rats were randomized into four groups as follows; control group (group C), group S (SWL + nephrectomy), group T (SWL + tadalafil given before nephrectomy) and group D (SWL + diltiazem given before nephrectomy). Both kidneys were evaluated regarding tubular damage, peritubular fibrosis and heat shock protein-70 (HSP-70) immune-expression of glomeruli, cortical and medullar collector tubules on light microscopy.
RESULTS: HSP-70 levels of cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group T compared with group S. Similarly, HSP-70 immunostaining levels on cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group D compared with group S. No significant difference was detected between group D and group T for all parameters.
CONCLUSION: As a result, shock waves induced renal cell damage due to increment of HSP-70 levels, morphological irregularity in tubules and increased peritubular fibrosis. Tadalafil and diltiazem had beneficial effects in decreasing renal tissue damage which was caused by SWL (Tab. 2, Fig. 6, Ref. 29).

Bratisl Lek Listy. 2017;118(4):228-232. doi: 10.4149/BLL_2017_045.

 

 

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Comments 1

Peter Alken on Wednesday, 15 November 2017 08:43

I do not think that the rat is a good animal model to study the side-effects of ESWL. 1500 shots with 14 kv on a fingernail-size organ seems to me to be just a renal trauma model but without any meaningful relation to clinically applied ESWL. The agents tadalafil and diltiazem were dissolved in saline and applied through an orogastric tube 60 min before the SWL procedure. It is not mentioned how the animals were prepared - no food, no drinking water - before the experiments. Data on serum concentrations of the drugs are not given.

I do not think that the rat is a good animal model to study the side-effects of ESWL. 1500 shots with 14 kv on a fingernail-size organ seems to me to be just a renal trauma model but without any meaningful relation to clinically applied ESWL. The agents tadalafil and diltiazem were dissolved in saline and applied through an orogastric tube 60 min before the SWL procedure. It is not mentioned how the animals were prepared - no food, no drinking water - before the experiments. Data on serum concentrations of the drugs are not given.
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