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Woźniak P et al., 2018: The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy

Woźniak P, Kontek B, Różański W, Olas B.
2nd Department of Urology, Medical University of Łódź, Pabianicka 62, 93-513 Łódź, Poland.
Department of General Biochemistry, Faculty of Biology & Environmental Protection, University of Łódź, Pomorska 141/3, 90-236 Łódź, Poland.

Abstract

AIM: To evaluate the level of lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy (ESWL). MATERIALS & METHODS: Isoprostane concentration (8-isoPGF2α) was measured in urine, and thiobarbituric acid reactive substance production in serum and erythrocytes. In addition, the concentrations of selected compounds (uric acid, glucose and creatinine) were measured in serum. RESULTS: The patients (before and after ESWL) demonstrated significantly higher levels of two different biomarkers of lipid peroxidation compared with the control group. A correlation was identified between increased amounts of uric acid and biomarkers of lipid peroxidation in patients with nephrolithiasis, both before and after ESWL. CONCLUSION: Uric acid may be associated with lipid peroxidation in patients with nephrolithiasis.

Future Med Chem. 2018 Dec 6. doi: 10.4155/fmc-2018-0149. [Epub ahead of print]

 

 

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Comments 1

Peter Alken on Tuesday, 23 April 2019 08:32

The core information concerning the effect of ESWL on the parameters evaluated is: no change after ESWL.
The stone patients were relatively sic compared to the controls: serum creatinine values of 1.67 ± 1.23 and uric acid of 8.5 ± 4.3 vs. 0.85 ± 0.16 and 4.5 ± 2.0 (mg/dl) respectively. I would not call them matched controls as the authors did.

The core information concerning the effect of ESWL on the parameters evaluated is: no change after ESWL. The stone patients were relatively sic compared to the controls: serum creatinine values of 1.67 ± 1.23 and uric acid of 8.5 ± 4.3 vs. 0.85 ± 0.16 and 4.5 ± 2.0 (mg/dl) respectively. I would not call them matched controls as the authors did.
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