Overview Cardiology
Overview Cardiology
Overview Cardiology
Overview Cardiology

A study of extracorporeal cardiac shock wave therapy combined with exercise rehabilitation in postoperative patients with PCI for CHD
Wan Q., Guo T., Li J., Ye X., Ji L., Chen Q., Liu Y., Xu B., He L.
Sci Rep. 2025 Jul 1;15(1):21670. doi:10.1038/s41598-025-05475-2
PMID:40594526

Cardiac shock wave therapy-induced exosome derived from OGD/R-treated H9c2 cells carrying miR-98-5p promote HUVECs angiogenesis 
Wu L., Li Z., Song W., Zhang L., Li K., Wang H. 
Sci Rep. 2025;15:15213. doi:10.1038/s41598-025-00104-4 

Clinical Outcomes of Cardiac Shockwave Therapy in Severe Coronary Artery Disease Patients after Coronary Artery Bypass Grafting
Wang J., Jia N., Liu B., Zhang R., Liu B., Lan M., Liu J., Yao Z., He Q.
Int Heart J. 2023;64(2):137-144. doi:10.1536/ihj.22-481
PMID:36927932

Cardioprotective effects of shock wave therapy: A cardiac magnetic resonance imaging study on acute ischemia-reperfusion injury
Petrusca L., Croisille P., Augeul L., Ovize M., Mewton N., Viallon M.
Front Cardiovasc Med. 2023;10:1134389. doi:10.3389/fcvm.2023.1134389
PMID:37180809

Attenuation of Myocardial Dysfunction in Hypertensive Cardiomyopathy Using Non-R-Wave-Synchronized Cardiac Shock Wave Therapy
Li F., Zhen Z., Sun S.J., Jiang Y., Liang W.H., Belau M., Storz R., Liao S.Y., Tse H.F.
Int J Mol Sci. 2022;23(21):13274. doi:10.3390/ijms232113274
PMID:36362064

Cardiac Shock Wave Therapy in Coronary Artery Disease: a Systematic Review and Meta-Analysis
Quan Qiu, Shenjie Chen, Yuangang Qiu, Wei Mao
Front Cardiovasc Med. 2022;9:932193. doi:10.3389/fcvm.2022.932193
PMID:35958405

Efficacy and safety of cardiac shock wave therapy for patients with severe coronary artery disease: A randomized, double-blind control study
Jia N., Zhang R., Liu B., Liu B., Qi X., Lan M., Liu J., Zeng P., Chen C., Li W., Guo Y., Yao Z., He Q.
J Nucl Cardiol. 2021;29(5):2404-2419. doi:10.1007/s12350-021-02768-7
PMID:34476776

Cardiac Shock Wave Therapy Ameliorates Myocardial Ischemia in Patients With Chronic Refractory Angina Pectoris: A Randomized Trial
Liu W., Fan X., Shen J., Zhu M., Fan X., Xu Y., Hong L.
Front Cardiovasc Med. 2021 Jul 21;8:664433. doi:10.3389/fcvm.2021.664433
PMID:34368242

Cardiac Shock Wave Therapy for Coronary Heart Disease: an Updated Meta-analysis
Hai-Tao Yang, Xiang Xie, Xian-Geng Hou, Wen-Juan Xiu, Ting-Ting Wu
Braz J Cardiovasc Surg. 2020;35(5):741-756. doi:10.21470/1678-9741-2019-0276
PMID:33118740

Extracorporeal cardiac shock waves therapy promotes function of endothelial progenitor cells through PI3K/AKT and MEK/ERK signaling pathways
Ma Y., Hu Z., Yang D., Li L., Wang L., Xiao J., Cao X., Shi Y., Cai H.
Am J Transl Res. 2020;12(7):3895-3905. doi:10.7150/ajtr.42785
PMID:32774743

Cardiac shock wave therapy protects cardiomyocytes from hypoxia-induced injury by modulating miR-210
Qiu Q., Shen T., Wang Q., Yu X., Jia N., He Q.
Mol Med Rep. 2020;21(2):631-640. doi:10.3892/mmr.2019.10892
PMID:31974607

Role of PI3K/Akt signaling pathway in ischemic rats underwent cardiac shock waves therapy 
Shang L.L., Su Z., Ma X.J., Wang Y.Q., Wang Y., Wang Q.X., Yang P.
Zhonghua Xin Xue Guan Bing Za Zhi. 2019;47(6):457-464. doi:10.3760/CMA.J.ISSN.0253-3758.2019.06.007
PMID:31262130

The effect of cardiac shock wave therapy on myocardial function and perfusion in the randomized, triple-blind, shamprocedure controlled study
Čelutkienė J., Burneikaitė G., Shkolnik E., Jakutis G., Vajauskas D., Čerlinskaitė K., Zuozienė G., Petrauskienė B., Puronaitė R., Komiagienė R., Butkuvienė I., Steponėnienė R., Misiūra J., Laucevičius A.
Cardiovasc Ultrasound. 2019;17(1):13. doi:10.1186/s12947-019-0163-1
PMID:31272465

A multicenter trial of extracorporeal cardiac shock wave therapy for refractory angina pectoris: report of the highly advanced medical treatment in Japan 
Kikuchi Y., Ito K., Shindo T., Hao K., Shiroto T., Matsumoto Y., Takahashi J., Matsubara T., Yamada A., Ozaki H., Hiroe M., Misumi K., Ota H., Takanami K., Hiraide K., Takase F., Tanji Y., Tomata Y., Ichiro Tsuji, Shimokawa H.
Heart Vessels. 2018;34(1):104-113. doi:10.1007/s00380-018-1215-4
PMID:29942978

Extracorporeal Shock Wave Therapy for Coronary Artery Disease: Relationship of Symptom Amelioration and Ischemia Improvement 
Takakuwa Y., Sarai M., Kawai H., Yamada A., Shiino K., Takada K., Nagahara Y., Miyagi M., Motoyama S., Toyama H., Ozaki Y. 
Asia Ocean J Nucl Med Biol. 2018; 6(1): 1-9. doi: 10.22038/aojnmb.2017.9899
PMID: 29333461

Cardiac shock wave therapy promotes arteriogenesis of coronary micrangium, and ILK is involved in the biomechanical effects by proteomic analysis
Wenhui Yang, Yan He, Lulu Gan, Fan Zhang, Baotong Hua, Ping Yang, Juan Liu, Li Yang, Tao Guo
Sci Rep. 2018;8(1):1814. doi:10.1038/s41598-018-19393-z
PMID:29379038

Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction: a first-in-human study
Kagaya Y., Ito K., Takahashi J., Matsumoto Y., Shiroto T., Tsuburaya R., Kikuchi Y., Hao K., Nishimiya K., Shindo T., Ogata T., Kurosawa R., Eguchi K., Monma Y., Ichijo S., Hatanaka K., Miyata S., Shimokawa H.
Coron Artery Dis. 2018;29(4):294–300. doi:10.1097/MCA.0000000000000577
PMID:29068804

Study of the Safety of Extracorporeal Cardiac Shock Wave Therapy: Observation of the Ultrastructures in Myocardial Cells by Transmission Electron Microscopy
Bing Liu, Yunhe Zhang, Na Jia, Ming Lan, Ling Du, Dachun Zhao, Qing He
J Cardiovasc Pharmacol Ther. 2018 Jan;23(1):79–88. doi:10.1177/1074248417725877
PMID:28862043

Shock Wave Therapy Promotes Cardiomyocyte Autophagy and Survival during Hypoxia.
Du, L; Shen, T; Liu, B; Zhang, Y; Zhao, C; Jia, N; Wang, Q; He, Q.
Cell Physiol Biochem. 2017;42(2):673-684.
PMID: 28618416 [Indexed for MEDLINE]

Cardiac shock-wave therapy in the treatment of coronary artery disease: systematic review and meta-analysis.
Burneikaitė, G; Shkolnik, E; Čelutkienė, J; Zuozienė, G; Butkuvienė, I; Petrauskienė, B; Šerpytis, P; Laucevičius, A; Lerman, A.
Cardiovasc Ultrasound. 2017 Apr 12;15(1):11.
PMID: 28403861 [Indexed for MEDLINE]

Clinical Effect of Cardiac Shock Wave Therapy on Myocardial Ischemia in Patients With Ischemic Heart Failure.
Wang, W; Liu, H; Song, M; Fang, W; Yuan, F.
J Cardiovasc Pharmacol Ther. 2016 Jul;21(4):381-7.
PMID: 26657563 [Indexed for MEDLINE]

Cardiac shock wave therapy shows better outcomes in the coronary artery disease patients in a long term.
Nirala, S; Wang, Y; Peng, YZ; Yang, P; Guo, T.
Eur Rev Med Pharmacol Sci. 2016;20(2):330-8.
PMID: 26875905 [Indexed for MEDLINE]

Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: roles of mechanotransduction.
Hatanaka, K; Ito, K; Shindo, T; Kagaya, Y; Ogata, T; Eguchi, K; Kurosawa, R; Shimokawa, H.
Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C378-85. Epub 2016 Jul 13.
PMID: 27413171 [Indexed for MEDLINE]

Effect of cardiac shock wave therapy on the microvolt T wave alternans of patients with coronary artery disease.
Zhao, L; Yang, P; Tang, Y; Li, R; Peng, Y; Wang, Y; Pu, L; Guo, T.
Int J Clin Exp Med. 2015 Sep 15;8(9):16463-71.
PMID: 26629172 [Indexed for MEDLINE]

Cardiac shockwave therapy improves myocardial function in patients with refractory coronary artery disease by promoting VEGF and IL-8 secretion to mediate the proliferation of endothelial progenitor cells. 
Cai, HY; Li, L; Guo, T; Wang, YU; Ma, TK; Xiao, JM; Zhao, L; Fang, Y; Yang, P; Zhao, HU.
Exp Ther Med. 2015 Dec;10(6):2410-2416. Epub 2015 Oct 20.
PMID: 26668649 [Indexed for MEDLINE]

Extracorporeal low-energy shock-wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction.
Abe, Y; Ito, K; Hao, K; Shindo, T; Ogata, T; Kagaya, Y; Kurosawa, R; Nishimiya, K; Satoh, K; Miyata, S; Kawakami, K; Shimokawa, H.
Circ J. 2014;78(12):2915-25. Epub 2014 Oct 2.
PMID: 25274132 [Indexed for MEDLINE]

Cardiac shock wave therapy attenuates H9c2 myoblast apoptosis by activating the AKT signal pathway.
Yu, W; Shen, T; Liu, B; Wang, S; Li, J; Dai, D; Cai, J; He, Q.
Cell Physiol Biochem. 2014;33(5):1293-303.
PMID: 24802592 [Indexed for MEDLINE]

Cell biological effects of mechanical stimulations generated by focused extracorporeal shock wave applications on cultured human bone marrow stromal cells.
Suhr, F; Delhasse, Y; Bungartz, G; Schmidt, A; Pfannkuche, K; Bloch, W.
Stem Cell Res. 2013 Sep;11(2):951-64.
PMID: 23880536 [Indexed for MEDLINE]

An experience of the use of a curative method of cardiac shock wave therapy in patients with ischemic heart disease
Gabrusenko S.A., Malakhov V.V., Shitov V.N., Sankova A.N., Sergienko V.B., Masenko V.P., Kukharchuk V.V.
Kardiologiia. 2013;53(5):20–26.
PMID:23952990

Shock wave treatment improves nerve regeneration in the rat.
Mense, S; Hoheisel, U.
Muscle Nerve. 2013 May;47(5):702-10. Epub 2013 Mar 16.
PMID: 23505053 [Indexed for MEDLINE]

Extracorporeal cardiac shock wave therapy ameliorates myocardial fibrosis by decreasing the amount of fibrocytes after acute myocardial infarction in pigs.
Lei, PP; Tao, SM; Shuai, Q; Bao, YX; Wang, SW; Qu, YQ; Wang, DH.
Coron Artery Dis. 2013 Sep;24(6):509-15.
PMID: 23839111 [Indexed for MEDLINE]

Cardiac shock wave therapy for chronic refractory angina pectoris. A prospective placebo-controlled randomized trial.
Schmid, JP; Capoferri, M; Wahl, A; Eshtehardi, P; Hess, OM.
Cardiovasc Ther. 2013 Jun;31(3):e1-6.
PMID: 22953794 [Indexed for MEDLINE]

A modified regimen of extracorporeal cardiac shock wave therapy for treatment of coronary artery disease.
Wang, Y; Guo, T; Ma, TK; Cai, HY; Tao, SM; Peng, YZ; Yang, P; Chen, MQ; Gu, Y.
Cardiovasc Ultrasound. 2012 Aug 17;10:35.
PMID: 22898340 [Indexed for MEDLINE]

Cardiac shock wave therapy: assessment of safety and new insights into mechanisms of tissue regeneration.
Di Meglio, F; Nurzynska, D; Castaldo, C; Miraglia, R; Romano, V; De Angelis, A; Piegari, E; Russo, S; Montagnani, S.
J Cell Mol Med. 2012 Apr;16(4):936-42.
PMID: 21790971 [Indexed for MEDLINE]

Extracorporeal shock wave therapy improves the walking ability of patients with peripheral artery disease and intermittent claudication.
Serizawa, F; Ito, K; Kawamura, K; Tsuchida, K; Hamada, Y; Zukeran, T; Shimizu, T; Akamatsu, D; Hashimoto, M; Goto, H; Watanabe, T; Sato, A; Shimokawa, H; Satomi, S.
Circ J. 2012;76(6):1486-93. Epub 2012 Mar 3.
PMID: 22447002 [Indexed for MEDLINE]

Shockwave therapy in patients with peripheral artery disease.
Ciccone, MM; Notarnicola, A; Scicchitano, P; Sassara, M; Carbonara, S; Maiorano, M; Moretti, B.
Adv Ther. 2012 Aug;29(8):698-707. Epub 2012 Aug 2.
PMID: 22869515 [Indexed for MEDLINE]

Randomized and double-blind controlled clinical trial of extracorporeal cardiac shock wave therapy for coronary heart disease. 
Yang, P; Guo, T; Wang, W; Peng, YZ; Wang, Y; Zhou, P; Luo, ZL; Cai, HY; Zhao, L; Yang, HW.
Heart Vessels. 2013 May;28(3):284-91.
PMID: 22457097 [Indexed for MEDLINE]

Extracorporeal shock wave therapy for ischemic cardiovascular disorders.
Ito, K; Fukumoto, Y; Shimokawa, H.
Am J Cardiovasc Drugs. 2011 Oct 1;11(5):295-302.
PMID: 21846155 [Indexed for MEDLINE]

Extracorporeal shock wave therapy induces therapeutic lymphangiogenesis in a rat model of secondary lymphoedema.
Serizawa, F; Ito, K; Matsubara, M; Sato, A; Shimokawa, H; Satomi, S.
Eur J Vasc Endovasc Surg. 2011 Aug;42(2):254-60.
PMID: 21454105 [Indexed for MEDLINE]

Cardiac shock wave therapy ameliorates left ventricular remodeling after myocardial ischemia-reperfusion injury in pigs in vivo.
Ito, Y; Ito, K; Shiroto, T; Tsuburaya, R; Yi, GJ; Takeda, M; Fukumoto, Y; Yasuda, S; Shimokawa, H.
Coron Artery Dis. 2010 Aug;21(5):304-11.
PMID: 20617568 [Indexed for MEDLINE]

Cardiac shock wave therapy reduces angina and improves myocardial function in patients with refractory coronary artery disease.
Wang, Y; Guo, T; Cai, HY; Ma, TK; Tao, SM; Sun, S; Chen, MQ; Gu, Y; Pang, JH; Xiao, JM; Yang, XY; Yang, C.
Clin Cardiol. 2010 Nov;33(11):693-9.
PMID: 21089114 [Indexed for MEDLINE]

Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris.
Kikuchi, Y; Ito, K; Ito, Y; Shiroto, T; Tsuburaya, R; Aizawa, K; Hao, K; Fukumoto, Y; Takahashi, J; Takeda, M; Nakayama, M; Yasuda, S; Kuriyama, S; Tsuji, I; Shimokawa, H.
Circ J. 2010 Mar;74(3):589-91. Epub 2010 Feb 4.
PMID: 20134096 [Indexed for MEDLINE]

[Cardiac shock wave therapy--a new method for treatment of advanced coronary disease and refractory angina].
Sobczak, M; Kasprzak, JD.
Kardiol Pol. 2010 Dec;68(12):1391-6.
PMID: 21174300 [Indexed for MEDLINE]

Extracorporeal shock wave therapy as a new and non-invasive angiogenic strategy.
Ito, K; Fukumoto, Y; Shimokawa, H.
Tohoku J Exp Med. 2009 Sep;219(1):1-9.
PMID: 19713678 [Indexed for MEDLINE]

Extracorporeal shock wave therapy in inflammatory diseases: molecular mechanism that triggers anti-inflammatory action.
Mariotto, S; de Prati, AC; Cavalieri, E; Amelio, E; Marlinghaus, E; Suzuki, H.
Curr Med Chem. 2009;16(19):2366-72.
PMID: 19601786 [Indexed for MEDLINE]

Extracorporeal shock wave therapy ameliorates hindlimb ischemia in rabbits.
Oi, K; Fukumoto, Y; Ito, K; Uwatoku, T; Abe, K; Hizume, T; Shimokawa, H.
Tohoku J Exp Med. 2008 Feb;214(2):151-8.
PMID: 18285673 [Indexed for MEDLINE]

Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart.
Nurzynska, D; Di Meglio, F; Castaldo, C; Arcucci, A; Marlinghaus, E; Russo, S; Corrado, B; de Santo, L; Baldascino, F; Cotrufo, M; Montagnani, S.
Ultrasound Med Biol. 2008 Feb;34(2):334-42. Epub 2007 Oct 29.
PMID: 17913335 [Indexed for MEDLINE]

Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs.
Uwatoku, T; Ito, K; Abe, K; Oi, K; Hizume, T; Sunagawa, K; Shimokawa, H.
Coron Artery Dis. 2007 Aug;18(5):397-404.
PMID: 17627190 [Indexed for MEDLINE]

Extracorporeal cardiac shock wave therapy: first experience in the everyday practice for treatment of chronic refractory angina pectoris. 
Khattab, AA; Brodersen, B; Schuermann-Kuchenbrandt, D; Beurich, H; Tölg, R; Geist, V; Schäfer, T; Richardt, G.
Int J Cardiol. 2007 Sep 14;121(1):84-5. Epub 2006 Nov 9.
PMID: 17097167 [Indexed for MEDLINE]

Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease.
Fukumoto, Y; Ito, A; Uwatoku, T; Matoba, T; Kishi, T; Tanaka, H; Takeshita, A; Sunagawa, K; Shimokawa, H.
Coron Artery Dis. 2006 Feb;17(1):63-70.
PMID: 16374144 [Indexed for MEDLINE]

Extracorporeal shock waves: from lithotripsy to anti-inflammatory action by NO production. 
Mariotto, S; Cavalieri, E; Amelio, E; Ciampa, AR; de Prati, AC; Marlinghaus, E; Russo, S; Suzuki, H.
Nitric Oxide. 2005 Mar;12(2):89-96.
PMID: 15740982 [Indexed for MEDLINE]

Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves.
Ciampa, AR; de Prati, AC; Amelio, E; Cavalieri, E; Persichini, T; Colasanti, M; Musci, G; Marlinghaus, E; Suzuki, H; Mariotto, S.
FEBS Lett. 2005 Dec 19;579(30):6839-45. Epub 2005 Nov 28.
PMID: 16325181 [Indexed for MEDLINE]

Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo.
Nishida, T; Shimokawa, H; Oi, K; Tatewaki, H; Uwatoku, T; Abe, K; Matsumoto, Y; Kajihara, N; Eto, M; Matsuda, T; Yasui, H; Takeshita, A; Sunagawa, K.
Circulation. 2004 Nov 9;110(19):3055-61. Epub 2004 Nov 1.
PMID: 15520304 [Indexed for MEDLINE]

Therapeutic ultrasound in cardiology.
Nesser, HJ; Karia, DH; Tkalec, W; Pandian, NG.
Herz. 2002 May;27(3):269-78.
PMID: 12096656 [Indexed for MEDLINE]

Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment.
Gotte, G; Amelio, E; Russo, S; Marlinghaus, E; Musci, G; Suzuki, H.
FEBS Lett. 2002 Jun 5;520(1-3):153-5.
PMID: 12044888 [Indexed for MEDLINE]

Effects of shock waves on the microcirculation in critical limb ischemia (CLI) (8-week study).
De Sanctis, MT; Belcaro, G; Nicolaides, AN; Cesarone, MR; Incandela, L; Marlinghaus, E; Griffin, M; Capodanno, S; Ciccarelli, R.
Angiology. 2000 Aug;51(8 Pt 2):S69-78.
PMID: 10959513 [Indexed for MEDLINE]

Shock waves (SW) noninvasive extracorporeal thrombolysis treatment (NISWT).
Belcaro, G; Nicolaides, AN; Cesarone, MR; De Sanctis, MT; Laurora, G; Incandela, L; Errichi, BM; Marlinghaus, EH; Pellegrini, L; Barsotti, A; Dugall, M.
Angiology. 1999 Sep;50(9):707-13.
PMID: 10496496 [Indexed for MEDLINE]

Shock waves in vascular diseases: an in-vitro study.
Belcaro, G; Nicolaides, AN; Marlinghaus, EH; Cesarone, MR; Incandela, L; De Sanctis, MT; Dhanjil, S; Laurora, G; Ramaswami, G; Artese, L; Ferrero, G; Ricci, A; Barsotti, A; Ledda, A; Steigerwalt, R; Griffin, M.
Angiology. 1998 Oct;49(10):777-88.
PMID: 9783642 [Indexed for MEDLINE]