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Popova E. et al., 2025: Kidney Stones as Minerals: How Methods from Geology Could Inform Urolithiasis Treatment.

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Elena Popova 1, Sergey Tkachev 2, Artur Shapoval 3, Anastasia Karpenko 2, Yuliya Lee 4, Pavel Chislov 4, Boris Ershov 2, Danila Golub 2, Gevorg Galechyan 2, Daniil Bogoedov 5, Anastasiya Akovantseva 6, Elvira Gafarova 2, Roman Musaelyan 7, Maria Schekleina 8, Stuart Clark 3, Stanislav Ali 4, Alim Dymov 4, Andrey Vinarov 4, Petr Glybochko 4, Peter Timashev 2
1Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Moscow 115682, Russia.
2Institute for Regenerative Medicine, Sechenov University, Moscow 119991, Russia.
3School of Minerals and Energy Resources Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
4Institute for Urology and Reproductive Health, Sechenov University, Moscow 119991, Russia.
5GridPoint Dynamics LLC, Moscow 123060, Russia.
6N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow 119334, Russia.
7Dokuchaev Soil Science Institute, Moscow 109017, Russia.
8Department of Petrology and Volcanology, Moscow State University, Moscow 119991, Russia.

Abstract

espite the recent advances in minimally invasive surgery, kidney stones still pose a significant clinical challenge due to their high recurrence rate of 50% in 5-10 years after the first stone episode. Using the methods of geosciences and biology, the GeoBioMed approach treats kidney stones as biogenic minerals, offering a novel perspective on their formation and dissolution processes. In this review, we discuss kidney stones' structural and mechanical properties as emerging biomarkers of urolithiasis, emphasizing the importance of a comprehensive stone analysis in developing personalized treatment strategies. By focusing on unexplored properties like crystalline architecture, porosity, permeability, cleavage, and fracture, alongside the conventionally used composition and morphology, we show how these stone characteristics influence the treatment efficacy and the disease recurrence. This review also highlights the potential of advanced imaging techniques to uncover novel biomarkers, contributing to a deeper understanding of stone pathogenesis. We discuss how the interdisciplinary collaboration within the GeoBioMed approach aims to enhance the diagnostic accuracy, improve the treatment outcomes, and reduce the recurrence of urolithiasis.

J Clin Med. 2025 Feb 5;14(3):997. doi: 10.3390/jcm14030997. PMID: 39941670 FREE PMC ARTICLE

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Comments 1

Hans-Göran Tiselius
Hans-Göran Tiselius on Wednesday, 23 July 2025 11:00

This article is a review of various methods possible to apply in stone analysis. Factors of importance for stone fragmentation and recurrence are discussed in detail. The stone structure and mechanical properties are scrutinized. There is, however, no direct reference to SWL that might be of clinical benefit. But this extensive review of stone properties should be highly interesting for research on stone formation and in vitro experiments, if this still is a field that is of interest for young urologists…

Hans-Göran Tiselius

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This article is a review of various methods possible to apply in stone analysis. Factors of importance for stone fragmentation and recurrence are discussed in detail. The stone structure and mechanical properties are scrutinized. There is, however, no direct reference to SWL that might be of clinical benefit. But this extensive review of stone properties should be highly interesting for research on stone formation and in vitro experiments, if this still is a field that is of interest for young urologists… Hans-Göran Tiselius
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Monday, 17 November 2025