Tikkinen KAO. et al., 2026: A Multicenter Randomized Controlled Trial of Antimicrobial Prophylaxis to Prevent Urinary Tract Infections after Shockwave Lithotripsy for Urolithiasis: The APPEAL Trial.

Tikkinen KAO, Najafabadi BT, Hajebrahimi S. et al. 
Eur Urol 2025;88(6):543-51. Eur Urol. 2026 May 20:S0302-2838(26)02162-7. doi: 10.1016/j.eururo.2026.03.038. Epub ahead of print.

Abstract

no abstract available

Comment Peter Alken

This comment on the publication of Tikkinen is exactly in line with my comment on that paper. By routine patient selection antibiotics before or during ESWL can be avoided in the vast majority of patients.

See also: Tikkinen KAO, Tondroanamag F, Parpia S, Guyatt GH, Violette PD; APPEAL Trial Investigators. Reply to Vallée M, Stangl FP, Wagenlehner F et al's Letter to the Editor re: Tikkinen KAO, Najafabadi BT, Hajebrahimi S, et al. A Multicenter Randomized Controlled Trial of Antimicrobial Prophylaxis to Prevent Urinary Tract Infections After Shockwave Lithotripsy for Urolithiasis: The APPEAL Trial. Eur Urol 2025;88(6):543-51. Eur Urol. 2026 Jun 25:S0302-2838(26)02229-3. doi: 10.1016/j.eururo.2026.06.008. Epub ahead of print. PMID: 42350166.

Peter Alken